Methods and compositions for the detection of familial hypercholesterolemia
US4966837A · kind A · utility
4Cited by
3References
26Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 30, 1986 |
| Grant date | Oct 30, 1990 |
| Priority date | — |
| Expiry date | Oct 30, 2006 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/825
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Recombinant DNA transfer vectors containing DNA inserts which are complementary to either the human LDL receptor gene, or its mRNA transcript, are disclosed. Also disclosed are methods which utilize these genetic probes for diagnosing Familial Hypercholesterolemia (FH) in a suspected individual. A case study of numerous such individual are disclosed wherein the genetic deletion mutation is detailed with great precision through the practice of this invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.