Expression of interferon genes in Chinese hamster ovary cells
US4966843A · kind A · utility
50Cited by
2References
21Claims
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Key dates
| Filing date | Jul 31, 1985 |
| Grant date | Oct 30, 1990 |
| Priority date | — |
| Expiry date | Jul 31, 2005 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/811
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
DNA constructs are prepared which operably link human interferon genes, selective, eukaryotic marker genes, and promoter and expression control sequences for the expression of human interferon in Chinese hamster ovary (CHO) cells or progeny thereof. The human recombinant interferon so produced contains glycans which are a subset of the population of glycans which are contained in the native counterpart, and may be used in therapeutic formulations. The CHO cells yield high levels of human interferon with no detectable amounts of host IFN, either constitutive or inductive.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.