Pyrrole derivatives, their preparation and their use as pharmaceutical active compounds

US4966901A · kind A · utility

Assignee

• Cassella Aktiengesellschaft · DE

Inventors

• Gerhard Zoller · Blankenloch, DE
• Rudi Beyerle · Frankfurt, DE
• Ursula Schindler · Bad Soden, DE

Key dates

• Filing date: May 23, 1989
• Grant date: Oct 30, 1990
• Expiry date: May 23, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Pyrrole derivatives of the general formula I ##STR1## wherein R denotes alkyl which is substituted by --NH.sub.2 or acylamino, R.sup.1 and R.sup.2 independently of one another denote hydrogen or alkyl having 1 to 4 carbon atoms, R.sup.3 denotes hydrogen, alkyl having 1 to 4 carbon atoms or a carboxylic acid grouping, R.sup.4 denotes a carboxylic acid grouping, nitro, alkylsulphinyl having 1 to 4 carbon atoms, optionally substituted phenylsulphinyl, alkylsulphonyl having 1 to 4 carbon atoms, optionally substituted phenylsulphonyl, alkylcarbonyl having 1 to 6 carbon atoms in the alkyl part, trifluoromethylcarbonyl, optionally substituted phenylcarbonyl, dicyanomethylene, formylvinyl, alkoxycarbonylvinyl having 1 to 6 carbon atoms in the alkoxy part or a carbonyl group, which is substituted by an optionally substituted aliphatic or aromatic 5- to 7-membered heterocyclic radical having 1 or 2 hetero atoms from the series comprising N, O and S, and pharmaceutically acceptable salts or acid addition salts thereof which are useful pharmacological active compounds. The invention also relates to methods for preparing the present compounds. The invention also includes formulations containing…