Method for preparing 1-chloro-5-alkylisoquinolines condensed with aromatic groups
US4966971A · kind A · utility
2Cited by
0References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 14, 1988 |
| Grant date | Oct 30, 1990 |
| Priority date | — |
| Expiry date | Nov 14, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D495/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
To prepare the compound (I), a lithiation of the compound (II) is performed, an aldehyde (IV) is reacted with the compound (III) formed, leading to the secondary alcohol (V) which is subjected to a reduction leading to the compound (VI), which is then subjected to a hydrolysis (of the dioxolane group)/cyclization/dehydration reaction. The procedure may be followed by a nucleophilic substitution reaction of the chlorine. The compounds (a) below exhibit antitumor activity. ##STR1## R=C.sub.1 -C.sub.3 alkyl; Ar=aromatic or polycyclic aromatic group; R.sub.1 and r.sub.2 =H or C.sub.1 -C.sub.3 alkyl; and n=2 to 4. No drawing.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.