Oral sustained release acetaminophen formulation and process
US4968509A · kind A · utility
129Cited by
1References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 19, 1989 |
| Grant date | Nov 6, 1990 |
| Priority date | — |
| Expiry date | Jan 19, 2009 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/165
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An acetaminophen-sustained release tablet or tablet layer is formed by making a wet granulation, using Povidone (PVP) in water or alcohol-water as the granulating fluid which is mixed with acetaminophen, hydroxyethyl cellulose, a wicking agent e.g. microcrystalline cellulose, then drying and milling the granulation and blending with dry powdered erosion promoter, e.g. pregelatinized starch, wicking agent, lubricant e.g. magnesium stearate and glidant e.g. silicon dioxide, and compressing the resultant granulation, which upon administration results in a slow release of the acetaminophen.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.