Certain 2,6-diisopropyl-4-(4-fluoro-phenyl)-3,5-bis-dimethyl-3',5'-dihydroxy-hep t-6-enoate-pyridine derivatives useful for treating lipoproteinaemia and arteriosclerosis

US4968689A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Rolf Angerbauer · Wuppertal, DE
• Peter Fey · Wuppertal, DE
• Walter Hubsch · Wuppertal, DE
• Thomas Philipps · Cologne, DE
• Hilmar Bischoff · Wuppertal, DE
• Dieter Petzinna · Mülheim an der Ruhr, DE
• Delf Schmidt · Wuppertal, DE
• Thomas Gunter · Arese, IT

Key dates

• Filing date: Jan 17, 1989
• Grant date: Nov 6, 1990
• Expiry date: Jan 17, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

For the treatment of lipoproteinaemia and arteriosclerosis, the new disubstituted pyridines of the formula ##STR1## in which R.sup.1 is optionally substituted aryl or heteroaryl, PA1 R.sup.2 is cycloalkyl or optionally substituted alkyl, PA1 R.sup.3 is hydrogen, cycloalkyl, or optionally substituted alkyl, aryl or heteroaryl, PA1 X is --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--, PA1 A is ##STR2## R.sup.6 is hydrogen or alkyl, and R.sup.7 is hydrogen, alkyl, aralkyl or a cation.