3-deazaneplanocin, intermediates for it, and antiviral composition and method of treatment using it

US4968690A · kind A · utility

Assignee

• United States Government as represented by the Secretary of the Dept. of Health and Human Services · US

Inventors

• Victor E. Marquez · Gaithersburg, US
• John S. Driscoll · Rockville, US
• Mu-Ill Lim · Trumbull, US
• Christopher K. Tseng · Burtonsville, US
• Alberto Haces · Gaithersburg, US
• Robert I. Glazer · Gaithersburg, US

Key dates

• Filing date: Jan 19, 1989
• Grant date: Nov 6, 1990
• Expiry date: Jan 19, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The new compound 3-deazaneplanocin A has been discovered to have potent anti-viral, anti-tumor activity and differentiating activity. A simple method for preparing 3-deazaneplanocin A has been developed involving nucleophilic substitution, which method can also be used to prepare a great variety of carbocyclic nucleosides.