Pyrido[1,2-a]indoles and their use as CNS agents

US4968699A · kind A · utility

Assignee

• Beecham-Wuelfing GmbH & Co. KG · DE

Inventors

• Dagmar Hoeltje · Gehrden, DE
• Ljerka Jozic · Gronau, DE
• Dietrich Thielke · Wallenstedt, DE

Key dates

• Filing date: Dec 21, 1987
• Grant date: Nov 6, 1990
• Expiry date: Dec 21, 2007

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/435
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein: R.sub.1 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy or halogen; PA1 R.sub.2 and R.sub.3 are both hydrogen or together represent a bond; PA1 R.sub.4 is hydrogen and R.sub.5 is hydrogen or R.sub.4 and R.sub.5 together represent an oxo group; PA1 R.sub.6 is phenyl C.sub.1-7 alkanoyl in which the phenyl moiety is optionally substituted by one or two of halogen, nitro, meta- or para-methoxy, methyl or NR.sub.8 R.sub.9 wherein R.sub.8 and R.sub.9 are independently hydrogen or C.sub.1-6 alkyl or R.sub.8 and R.sub.9 together are C.sub.2-6 polymethylene, or 3,4-disubstituted by methylenedioxy or ethylenedioxy; or C.sub.1-7 alkanoyl substituted by NR.sub.10 R.sub.11 where R.sub.10 and R.sub.11 are independently hydrogen or C.sub.1-4 alkyl or together are C.sub.3-7 polymethylene optionally containing a further heteroatom which is oxygen, sulphur or nitrogen substituted by R.sub.12 where R.sub.12 is hydrogen, C.sub.1-4 alkyl or benzyl, and optionally substituted by one or two C.sub.1-4 alkyl, C.sub.2-5 alkanoyl, C.sub.1-4 alkoxycarbonyl, aminocarbonyl optionally…