Benzopyrrolidinone compounds as bronchospastic agents
US4968705A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 10, 1989 |
| Grant date | Nov 6, 1990 |
| Priority date | — |
| Expiry date | Aug 10, 2009 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P37/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
New benzopyrrolidinone compounds, which can be used as medicaments and correspond to the formula ##STR1## in which: either: R.sub.1 and R.sub.2 together represent, with the bond of the etherocycle to which they are attached, an optionally substituted benzene nucleus and, simultaneously, R.sub.3 and R.sub.4 are hydrogen, (C.sub.1 -C.sub.4)alkyl or (C.sub.5 -C.sub.6)cycloalkyl; or: PA2 R.sub.1 is hydrogen, R.sub.4 is a single bond and R.sub.2 and R.sub.3 together represent, with the bond of the heterocycle to which they are bonded, an optionally substituted benzene nucleus; and PA2 A is a straight or branched hydrocarbon chain having from 2 to 6 carbon atoms that is optionally substituted by hydroxy; PA2 X is a single bond, oxygen or sulphur; and PA2 Y is hydrogen, halogen or (C.sub.1 -C.sub.5)alkyl or alkoxy. These new compounds and the physiologically tolerable salts thereof can be used therapeutically, especially in the treatment of bronchospastic disorders and inflammations in the ENT area.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.