Thieno-traizolo-1,4-diazepino-2-carboxylic acid amides

US4968794A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Karl-Heinz Weber · Gau-Algesheim, DE
• Albrecht Harreus · Ingelheim am Rhein, DE
• Jorge C. Stenzel · Mainz, DE
• Gojko Muacevic · Ingelheim am Rhein, DE
• Wolfgang Troger · Stromberg, DE
• Gerhard Walther · Bingen, DE

Key dates

• Filing date: Oct 3, 1988
• Grant date: Nov 6, 1990
• Expiry date: Oct 3, 2008

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to new thieno-traizolo-1,4-diazepino-2-carboxylic acid amides of formula I ##STR1## wherein R.sub.1 represents hydrogen, a C.sub.1 -C.sub.4 straight-chained or branched alkyl which can optionally be substituted by halogen, preferably Cl or Br, or by hydroxy, cyclopropyl, C.sub.1 -C.sub.3 alkoxy, preferably methoxy, or halogen, preferably chlorine or bromine; PA1 R.sub.2 and R.sub.3, each independently, represent hydrogen, a C.sub.1 -C.sub.4 straight-chained or branched alkyl, C.sub.1 -C.sub.4 hydroxyalkyl or the two groups R.sub.2 and R.sub.3 together with the nitrogen atom represent a 5-, 6- or 7-membered ring which optionally contains a nitrogen, oxygen or sulfur atom as a further heteroatom, the second nitrogen atom optionally being substituted by a C.sub.1 -C.sub.4 alkyl, preferably a methyl group; PA1 R.sub.4 represents alpha-pyridyl or a phenyl in which the phenyl ring can be substituted preferably in the 2-position, by methyl, halogen, preferably chlorine or bromine, nitro or trifluoromethyl; PA1 n represents one of the numbers 0, 1, 2, 3, 4, 5, 6, 7 or 8; and novel intermediates therefor. The compounds of formula I are useful in the treatment of pathol…