Process for the production ergoline derivatives

US4968801A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Gerhard Sauer · Berlin, DE
• Helmut Biere · Berlin, DE
• Gregor Haffer · Berlin, DE
• Andreas Huth · Berlin, DE

Key dates

• Filing date: May 25, 1989
• Grant date: Nov 6, 1990
• Expiry date: May 25, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D457/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Ergoline derivatives of general Formula I ##STR1## wherein C.sub.8 C.sub.9 and C.sub.9 C.sub.10 are both CC-single bonds or one is a C.dbd.C-double bond, PA0 R.sup.6 is C.sub.1-4 alkyl, PA0 R.sup.8 is methyl, hydroxymethyl, carbonylmethoxy, ureido or N,N-diethylureido, each in the .alpha.- or .beta.-position, and PA0 R is hydrogen or nitro, are prepared by dehydrogenation of corresponding 2,3-dihydroergoline derivatives using an electrophilic reagent in an apolar solvent and a base.