Process for the preparation of nitroethene derivatives

US4968808A · kind A · utility

Assignee

• Heumann Pharma GmbH · DE

Inventors

• Peter Mosdorf · Langenzenn, DE
• Helmut Schickaneder · Eckental, DE
• Kurt H. Ahrens · Nürnberg, DE

Key dates

• Filing date: Apr 1, 1988
• Grant date: Nov 6, 1990
• Expiry date: Apr 1, 2008

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D277/28
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A new process for the preparation of the nitroethane derivatives, ranitidine and nizatidine, is described which takes place via intermediate products and enables the said compounds to be prepared with a higher degree of purity. Another advantage is that in contrast to the known processes, it is not accompanied by the liberation of the highly toxic and malodorous compound, methylmercaptan.