Patent · US Expired

(S)-Alkyl 3-(thien-2-ylthio)butyrate and analogs and synthesis thereof

US4968814A · kind A · utility

8Cited by

3References

4Claims

0Family size

Assignee

MERCK & CO., INC. · US

Inventors

Thomas J. Blacklock · Clark, US
Edward J. J. Grabowski · Westfield, US
Paul Sohar · Hackettstown, US

Key dates

Filing date	Apr 18, 1990
Grant date	Nov 6, 1990
Priority date	—
Expiry date	Apr 18, 2010

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P43/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

(S)-Alkyl 3-(thien-2-ylthio)butyrate and analogs are intermediates in the synthesis of the chiral (S,S)-5,6-dihydro-4-ethylamino-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfon amide-7,7-dioxide and analogs thereof, topically effective carbonic anhydrase inhibitors useful in the treatment of ocular hypertension and glaucoma.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.