Controlled-release, low-dose aspirin formulation and method of treating vascular occlusive disease therewith
US4970081A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jan 3, 1989 |
| Grant date | Nov 13, 1990 |
| Priority date | — |
| Expiry date | Jan 3, 2009 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/60
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An aqueous-based formulation for coating aspirin granules to provide granules that may be compressed into tablets and that show approximately zero-order release kinetics for release rates of 5 to 15 mg/hour over a period extending five to eight hours is provided. The coating formulation preferably consists of an acrylate/methacrylate copolymer, hydroxypropylmethylcellulose, sodium chloride and talc. A film-coated tablet comprised of the coated granules, filler granules, excipients, binders and disintegrants is also provided, as are processes for preparing the tablets and granules and methods for their use in the treatment of vascular occlusive diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.