Human interferon-gamma
US4970161A · kind A · utility
6Cited by
0References
4Claims
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Key dates
| Filing date | Jan 19, 1988 |
| Grant date | Nov 13, 1990 |
| Priority date | — |
| Expiry date | Jan 19, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/57
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A DNA sequence on which a chromosomal DNA sequence coding for human interferon-.gamma. (HuIFN-.gamma.) and having a TATA box is ligated to a sequence of a promoter. Cell cultures transformed with said DNA revealed a higher expression of HuIFN- than cell cultures transformed with a DNA which does not have such TATA box. When transformed with said DNA, cell cultures produced HuIFN-.gamma. in a serum free medium. Transformed cell cultures derived from blood cells of HuIFN-.gamma. resistant human cell-line also could produce HuIFN-.gamma..
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