2-methylthiomethyl-dihydropyridines and pharmaceutical compositions containing them
US4971984A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 10, 1987 |
| Grant date | Nov 20, 1990 |
| Priority date | — |
| Expiry date | Dec 10, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D211/90
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of formula I ##STR1## wherein R.sub.1 is a cyano, nitro, benzoyl, acetyl, amido or alkoxycarbonyl group; PA0 R.sub.2 is substituted aryl- or heterocyclic residue; PA0 R.sub.3 is alkoxycarbonyl group; PA0 R.sub.4 and R.sub.5, being the same or different, are hydrogen, alkyl, aryl or heterocyclic groups; PA0 Y is oxygen, sulphur or substituted or unsubstituted nitrogen atom, that can be a part of a heterocyclic ring; PA0 n is 0, 1 or 2 PA0 R6 and R.sub.10, that can be the same or different, are: hydrogen; C.sub.1 -C.sub.6 -alkyl optionally substituted by hydroxy, amino, monoalkyl and dialkylamino, C.sub.1 -C.sub.6 -alkoxy, C.sub.1 -C.sub.6 -alkoxycarbonyl, C.sub.1 -C.sub.3 -carbonyloxy, aryl, heteroaryl and cycloalkyl; a C.sub.1 -C.sub.12 -alkanoyl, aroyl or heteroaryl group optionally substituted by halogen, nitro, amino monoalkylamino, dialkylamino, hydroxy, C.sub.1 -C.sub.6 -alkoxy, C.sub.1 -C.sub.6 -alkoxycarbonyl, C.sub.1 -C.sub.6 -alkylthio, C.sub.1 -C.sub.3 -carbonyloxy, aryl, heteroaryl, cycloalkyl groups. These compounds are useful in therapy as cardiovascular agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.