FSH-releasing peptides
US4973577A · kind A · utility
83Cited by
4References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 31, 1987 |
| Grant date | Nov 27, 1990 |
| Priority date | — |
| Expiry date | Aug 31, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A 28,000-dalton protein with FSH-releasing activity is isolated from porcine follicular fluid in a multi-step procedure including gel filtration, ion exchange chromatography and several reverse-phase high-performance liquid chromatography steps. The 28 kD protein promotes secretion of FSH, but not of LH, in a rat anterior pituitary monolayer culture system, exhibiting an EC.sub.50 of 0.5 ng/ml. These peptides are dimers of inhibin .beta.-chains of mammals, and homodimers or heterodimers of the .beta..sub.A and .beta..sub.B chains are biologically active to regulate fertility of various mammalian species, including humans.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.