Synthetic peptides derived from the alpha-subunit of human lycoprotein hormones
US4973578A · kind A · utility
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7Claims
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Key dates
| Filing date | Mar 17, 1988 |
| Grant date | Nov 27, 1990 |
| Priority date | — |
| Expiry date | Mar 17, 2008 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/854
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Synthetic peptides corresponding to .alpha.-subunit of human glycoprotein hormone amino acid regions .alpha.31-45, .alpha.21-35, .alpha.26-46 and .alpha.81-92; were found to inhibit binding of 125.sub.I-bTSH to human thyroid. Peptides corresponding to regions .alpha.26-46 and .alpha.31-45 were also found to potently inhibit the stimulation of adenylate cyclase activity by bTSH in a TSH bioassay using FRTL-5 cells and block the action of thyroid stimulating immunoglobulin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.