Depolymerized dermatan sulfates endowed with an antithrombotic, fibrinolytic, antiinflammatory activity and pharmaceutical compositions containing such
US4973580A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 10, 1989 |
| Grant date | Nov 27, 1990 |
| Priority date | — |
| Expiry date | May 10, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08B37/0078
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Process for the preparation of oligosaccharides by a controlled chemical depolymerization of natural polysaccharides, such as heparins, heparan sulfates, dermatan sulfates, chondroitinsulfates, hyaluronic acid, by a radicalic reaction in an aqueous solution, at a temperature ranging between 20.degree. and 70.degree. C., in the presence of a catalyst selected in the group consisting of Cu++, Fe++, Cr+++, Cr.sub.2 O.sub.7 - as well as the resulting oligosaccharides and their related pharmaceutical compositions. The products exhibit high antithrombotic activity, little or no anticoagulant activity, high fibinolytic activity an antiinflammatory activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.