Carbaphens: aprophen analogs that are binary antidotes for organophosphate poisoning

US4973734A · kind A · utility

Assignee

• The United States of America as represented by the Secretary of the Army · US

Inventors

• Peter K. Chiang · Bethesda, US
• Haim Leader · Ramat HaSharon, IL
• Ruthann M. Smeikal · Silver Spring, US
• Richard K. Gordon · Potomac, US
• Charlotte S. Payne · Washington, US
• Bhupendra P. Doctor · Potomac, US
• Felipe N. Padilla · Wheaton, US

Key dates

• Filing date: Mar 17, 1989
• Grant date: Nov 27, 1990
• Expiry date: Mar 17, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C219/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel carbaphens are provided of the formula ##STR1## wherein R is OH, OCON(CH.sub.3).sub.2 or OCONHCH.sub.3, and R' is H, OH or .sub.2 OCON(CH.sub.3).sub.2, stereoisomers thereof, pharmaceutically-acceptable salts thereof or mixtures thereof. Compositions comprise the carbaphens with pharmaceutically acceptable carriers, and they may further comprise other drugs as well. Methods of treating patients either prophylactically or therapeutically which suffer from organophosphate poisoning, coronary insufficiency, cerebral vasospasms, spastic cholitis and cholecystitis comprise the administration of the carbaphens of the invention.