Stable solvent adducts of Z-1-(p-.beta.-dimethylaminoethoxy-phenyl)-1-(p-hydroxyphenyl)-2-phenyl-b ut-1-ene

US4973755A · kind A · utility

Assignee

• Heumann Pharma GmbH · DE

Inventors

• Ingomar Grafe · Nürnberg, DE
• Helmut Schickaneder · Eckental, DE
• Peter W. Jungblut · Hannover, DE
• Kurt H. Ahrens · Nürnberg, DE

Key dates

• Filing date: Apr 19, 1988
• Grant date: Nov 27, 1990
• Expiry date: Apr 19, 2008

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to new stereochemically pure and stable adducts of Z-1-(p-.beta.-dimethylaminoethoxyphenyl)-1-(p-hydroxyphenyl)-2-phenyl-but- 1-ene and certain solvents which by virtue of their marked antioestrogenic activities may be used for the therapeutic treatment of benign breast diseases and hormone-dependent mammary tumors, in particularly by percutaneous application.