Bioerodable sustained release implants
US4975280A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 23, 1989 |
| Grant date | Dec 4, 1990 |
| Priority date | — |
| Expiry date | Jan 23, 2009 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/2045
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A device for controlled release of one or more pharmacologically active substances within an animal which comprises (i) a body of a bioerodable solid state poly(amino acid ester) phosphazene polymer, and (ii) at least one pharmacologically active substance physically incorporated within said body. The device may comprise an implantable body in which the poly(amino acid ester)phosphazene polymer is a matrix within which such pharmacologically active substance is dispersed. Alternatively, the polymer may constitute a coating or container within which such pharmacologically active substance is physically encased--i.e., the polymer surrounds the active agent as in a capsule or in a microencapsulated form. Results of in vivo experiments using implants of poly[bis((ethyl glycino)phosphazene] containing 25% ethidium are described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.