Certain anti-inflammatory cyclohepta[b]pyridines and analogs thereof

US4975431A · kind A · utility

Assignee

• John Wyeth & Brother Limited · GB

Inventors

• Roger Crossley · Reading, GB
• Albert Opalko · Maidenhead, GB

Key dates

• Filing date: Jun 16, 1989
• Grant date: Dec 4, 1990
• Expiry date: Jun 16, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D215/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention concerns compounds of formula I ##STR1## or a salt thereof, wherein R.sup.1 and R.sup.2 each independently represent hydrogen, lower alkyl, lower alkoxy, carboxyloweralkyl, carboxy, hydroxyloweralkyl, halogen, haloloweralkyl, lower alkoxycarbonyl, optionally substituted aryl or optionally substituted aralkyl, n represents an integer from 3 to 6; R.sup.3 represents hydrogen or single or multiple substitution on one or more of the aliphatic carbons by one or more substituents selected from lower alkyl, optionally substituted aryl and optionally substituted aralkyl; A represents a group of formula (i) or (ii) below: EQU --CR.sup.4 R.sup.5 --(CR.sup.6 R.sup.7).sub.m -- (i) EQU --CX--(CR.sup.6 R.sup.7).sub.m -- (ii) in which R.sup.4, R.sup.6 and R.sup.7 each independently represent hydrogen or lower alkyl (providing that when R.sup.5 is NH.sub.2, R.sup.4 is hydrogen); m is O or 1; R.sup.5 represents hydrogen, NH.sub.2, OH or loweralkoxy, and X is .dbd.O, .dbd.NH or .dbd.NOH, the attachment of A to B being from either end, and B represents a optionally substituted aryl or heteroaryl radical which compounds possess anti-inflammatory activity. Also disclosed is a process for …