Bone collagen matrix for zenogenic implants
US4975526A · kind A · utility
161Cited by
8References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 17, 1989 |
| Grant date | Dec 4, 1990 |
| Priority date | — |
| Expiry date | Oct 17, 2009 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S623/923
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed is a matrix material for implantation in a mammalian host comprising biocompatible mineral-free type I bone collagen, xenogenic to the host, and biodegradable therewithin. The matrix is manufactured from protein-extracted bone powder treated with certain swelling agents to increase its surface area and porosity. The matrix may be combined with osteogenic protein to induce reliably and reproducibly endochondral bone formation. It also can be used as a surface coat around implantable prosthetic devices to promote cellular ingrowth or as a carrier for sustained release of various therapeutic compositions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.