Medicament formulation containing dihydropyridines and a process for its preparation

US4976964A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Klaus Schlossmann · Wuppertal, DE
• Alfred Zembrod · Bensberg, DE
• Stanislav Kazda · Wuppertal, DE
• Peter Serno · Bensberg, DE
• Bernd Klinksiek · Bensberg, DE

Key dates

• Filing date: Apr 16, 1986
• Grant date: Dec 11, 1990
• Expiry date: Apr 16, 2006

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T428/2984
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

In the parenteral administration of a dihydropyridine, the improvement which comprises administering the dihydropyridine in an aqueous medium of pH 3 to 8.5 having dispersed therein liposomes with an average diameter of 20-1000 nm, the liposome membrane containng the following constituents by weight: PA1 (a) a part of a dihydropyridine, and PA1 (b) 5-500 parts of lipids. The aqueous medium is storage stable and readily injectable.