Anhydrous delivery systems for pharmacological agents
US4976968A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Feb 24, 1989 |
| Grant date | Dec 11, 1990 |
| Priority date | — |
| Expiry date | Feb 24, 2009 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/1641
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Substantially anhydrous pharmacological agents microencapsulated within protective hollow proteinoid microspheres are produced by contacting an aqueous mixture of such agent with an insoluble proteinoid and lyophilizing the resulting microspheres. Such encapsulation and dehydration results in a free flowing powder that has a long shelf life under naturally occurring temperature conditions and that quickly reabsorbs water without damage to the capsular wall. Gastrointestinally labile or poorly absorbed agents, such as insulin, heparin or dopamine redox carrier system, which are so microencapsulated in protective microspheres are rapidly rehydrated by body fluids in the gastrointestinal tract. Those microspheres having a diameter of about 10 microns or less penetrate the gastrointestinal mucosa and release the agent into the bloodstream in physiologically active form.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.