Process for preparing 1,8-bridged 4-quinolone-3-carboxylic acid antibacterials

US4977263A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Michael Schriewer · Odenthal, DE
• Klaus Croche · Waging am See, DE
• Hans-Jonchim Zeiler · Valbert, DE
• Karl G. Hetzner · Wuppertal, DE

Key dates

• Filing date: Sep 25, 1989
• Grant date: Dec 11, 1990
• Expiry date: Sep 25, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Antibacterially active new 1,8-bridged 4-quinolone-3-carboxylic acid derivatives of the formula ##STR1## in which Y is carboxyl or a derivative thereof PA1 R.sup.1, R.sup.2, R.sup.3, X.sup.1, X.sup.2 and X.sup.5 are H or various radicals, PA1 Z is Om NH, substituted NH, ##STR2## m and n are 0 or 1, and A, B, D and E are CH or substituted C or up to three of them are N, and physiologically acceptable salts thereof. Novel intermediates are described as well as processes for making the intermediates and end products.