Fluorine-containing 2-nitroimidazole derivatives
US4977273A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Dec 12, 1989 |
| Grant date | Dec 11, 1990 |
| Priority date | — |
| Expiry date | Dec 12, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D233/91
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A 2-nitroimidazole derivative of the formula: ##STR1## wherein R.sub.f is a group of the following formula (II) or (III): EQU --CH.sub.2 CFXCH.sub.2 OR.sub.1 (II) wherein X is a hydrogen atom or a halogen atom; R.sub.1 is a group of the formula: ##STR2## wherein R.sub.2 is a hydrogen atom, a hydroxyl group, a C.sub.1 -C.sub.3 alkyl group, a C.sub.2 -C.sub.4 acyl group, benzylidene or acetonide; R.sub.3 is a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group; Z is a hydrogen atom, COOY, COOR.sub.3, CONHOY, CONR.sub.4 R.sub.5 (wherein R.sub.4 and R.sub.5 are hydroxyl group-containing C.sub.1 -C.sub.3 alkyl groups or hydrogen atoms; Y is a hydrogen atom or a monovalent metal atom), an amino group, a hydroxyl group or OR.sub.3 ; l is an integer of 1 to 3; o is an integer of 0 to 3; p is an integer of 0 to 2; q is an integer of 0 to 3; m and n are integers of 0 to 4; and 1.ltoreq.m+n.ltoreq.4 or ##STR3## wherein R.sub.3, X and p are the same as defined above; Z' is the same as Z or is OCOOCH.sub.3 ; r is an integer of 1 to 3; s is 0 or 1; t is an integer of 0 to 4 provided that when p=0, s.noteq.0 and at least one X is a fluorine atom; and a radiosensitizer comprising said nitroimidazole d…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.