Novel bacteriocin compositions for use as enhanced broad range bactericides and methods of preventing and treating microbial infection

US4980163A · kind A · utility

Assignee

• The Public Health Research Institute Of the City of New York, Inc. · US

Inventors

• Peter Blackburn · New York, US
• Sara-Ann Gusik · New York, US
• June Polak · Brooklyn, US
• Stephen D. Rubino · New York, US

Key dates

• Filing date: Mar 1, 1989
• Grant date: Dec 25, 1990
• Expiry date: Mar 1, 2009

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Broad range bacteriocin compositions are provided. The compositions can be dissolved or suspended in a suitable solvent or matrix and are more active towards a broader range of bacteria than are any of the component parts. The dissolved or suspended compositions constitute enhanced broad range bactericides. The compositions include lysostaphin and a lanthionine containing peptide bacteriocin; lysostaphin, a lanthionine containing peptide bacteriocin and a chelating agent; and lysostaphin, a lanthionine containing peptide, a chelating agent and a surfactant. Each component is present in the enhanced broad range bactericide in sufficient amount such that the bactericide is more effective against staphylococci than is lysostaphin alone and is more effective at treating and preventing a broad range of microbial infections. Methods of treating bacterial infections using said compositions and bactericides are provided.