4H-3,1-benzoxazin-4-one compounds and pharmaceutical compositions thereof for the inhibition of serine proteases
US4980287A · kind A · utility
9Cited by
1References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 3, 1989 |
| Grant date | Dec 25, 1990 |
| Priority date | — |
| Expiry date | Feb 3, 2009 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A 4H-3,1-benzoxazin-4-one compound of the formula (I): ##STR1## wherein R is a hydrogen atom or alkyl radical, A is an amino acid residue or a peptide having 2 to 3 amino acid residues, which amino acid residue may have a side chain thereof protected by a protective radical, X is an alkyl, fluoroalkyl, OR.sup.1 or NHR.sup.1 radical wherein R.sup.1 is an alkyl radical, and Y is a protective radical for an amino radical, and salts thereof, exhibit an excellent inhibitory activity against serine proteases, especially against human leukocyte elastase, and thus are useful as an effective component of a medicine for inhibiting elastase.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.