Process for the enzymatic separation of the optical isomers of racemic .alpha.-alkyl-substituted primary alcohols
US4980291A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 9, 1989 |
| Grant date | Dec 25, 1990 |
| Priority date | — |
| Expiry date | Feb 9, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P7/62
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Biotechnological resolution by means of enzymatic transesterification of the relevant racemic mixture of the optical isomers of .alpha.-alkyl-substituted primary alcohols having the formula (I): ##STR1## wherein: R represents a linear or branched (C.sub.1 -C.sub.20)-alkyl or alkenyl group or an aryl group, also substituted or condensed with other groups, in particular a group of formula (II) or (III): ##STR2## wherein: R.sup.ii represents a (C.sub.1 -C.sub.8)-alkyl group, a (C.sub.1 -C.sub.4)-alkenyl group, an alkoxy, phenyl, phenoxy, benzoyl, or heterocyclic group; PA2 R.sup.iii represents a hydrogen or halogen atom; PA2 R.sup.iv represents a (C.sub.1 -C.sub.4)-alkyl group, PA1 and wherein PA2 R.sup.i represents a (C.sub.1 -C.sub.4)-alkyl group either equal to, or different from, R, in the presence of an enzyme either free or immobilized on a support capable of selectively causing the S isomer to be esterified, with the R isomer being left substantially unchanged, said isomers being then separated according to techniques known from the prior art. The process is used in the synthesis of antiinflammatory agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.