Tetrahydronaphthalene and indane derivatives
US4980354A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 14, 1989 |
| Grant date | Dec 25, 1990 |
| Priority date | — |
| Expiry date | Sep 14, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2602/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to tetrahydronaphthalene and indane derivatives with the general formula I: ##STR1## wherein R.sup.1 represents zero to four substituents, which may be the same or different and are selected from OH, halogen, NO.sub.2, CN, CF.sub.3, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy and unsubstituted or C.sub.1 -C.sub.4 alkyl substituted amino; PA0 R.sup.2 represents C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkenyl and C.sub.1 -C.sub.4 alkynyl which may be substituted by halogen; PA0 R.sup.3 and R.sup.4 represent independently H, C.sub.1 -C.sub.4 alkyl or form together with the nitrogen atom a 5- or 6-membered ring; PA0 n has the value 0 or 1; PA0 ALK is an aliphatic hydrocarbon with 1-8 carbon atoms and their pharmaceutically acceptable salts. These new compounds are typical monoamine reuptake blockers with additional .alpha..sub.2 antagonist activity and show strong anti-depressant activity without being sedative. Compounds according to this invention are also suitable for treating patients with anxiety disorders, e.g. panic disorder.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.