Tryptamine compounds, and methods of cerebrovascular treatment therewith

US4980368A · kind A · utility

Assignee

• Beecham-Wuelfing GmbH & Co. KG · DE

Inventors

• Dietrich Thielke · Wallenstedt, DE
• Dagmar Hoeltje · Gehrden, DE

Key dates

• Filing date: Dec 23, 1986
• Grant date: Dec 25, 1990
• Expiry date: Dec 23, 2006

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D209/16
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein: R.sub.1 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy or halogen; PA1 R.sub.2 and R.sub.3 are both hydrogen or together represent a bond; PA1 R.sub.4 is selected from C.sub.1-6 alkyl, phenyl, phenyl C.sub.1-4 alkyl, COR.sub.8 where R.sub.8 is hydroxy, C.sub.1-6 alkoxy or NR.sub.9 R.sub.10 where R.sub.9 and R.sub.10 are independently hydrogen or C.sub.1-4 alkyl and CH.sub.2 OR.sub.11 and R.sub.11 is hydrogen, C.sub.1-4 alkyl or C.sub.1-4 alkanoyl; PA1 R.sub.5 is hydrogen, C.sub.1-6 alkyl or phenyl C.sub.1-4 alkyl; PA1 R.sub.6 is phenyl C.sub.1-7 alkyl in which the phenyl moiety is optionally substituted by one or two of halogen, ortho-nitro, meta- or para-methoxy, methyl or NR.sub.12 R.sub.13 wherein R.sub.12 and R.sub.13 are independently hydrogen or C.sub.1-6 alkyl or R.sub.12 and R.sub.13 together are C.sub.2-6 polymethylene or the phenyl moiety is 3,4-disubstituted by methylenedioxy or ethylenedioxy; and PA1 R.sub.7 is hydrogen or C.sub.1-4 alkyl, processes for its preparation and its use as a pharmaceutical.