Method of treating hormonal dependent mammary tumors in female mammals

US4981842A · kind A · utility

Assignee

• Roussel Uclaf · FR

Inventors

• Fernand Labrie · Ste. Anne, CA
• Jean-Pierre Raynaud · Paris, FR

Key dates

• Filing date: Apr 5, 1989
• Grant date: Jan 1, 1991
• Expiry date: Apr 5, 2009

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S930/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A novel method of treating prostate adenocarcinoma, prostate benign hypertrophia, endometriosis, dysmenorrhea, hirsuitism, hormono-dependant mammary tumors, treatment and prevention of precocious puberty, induction of a retardation of the appearance of puberty and treatment of acne of mammals comprising administering to warm-blooded animals an effective amount of a peptide of the formula EQU p Glu-His-Trp-Ser-Tyr-X-Y-Arg-Pro-Z (I) wherein (a) z is Gly-NH.sub.2, Y is Leu and X is Gly, (b) Z is Gly-NH.sub.2, Y is Leu, X is DN Leu, DN Val, D ABu (.alpha.-aminobutyric acid), D Phe, D SEr, D Thr, D Met, D Pgl, D Lys, Leu, Ile, Nle, Val, N Val, Met, Phe, D Leu, D Arg, D SEr (tbu), D Thr (tbu), D Cys (tbu), D Asp (O tbu), D Glu (Otbu), D Orn (boc), D Lys (boc), D TRp, Trp, 2-methyl Ala, D Tyr, .epsilon.-lauryl-D Lys, .alpha.-dextran-D Lys, (c) Z is HH-cyclopropyl-or NH-Alk wherein Alk is alkyl of 1 to 3 carbon atoms, Y is Leu and X is D Ser (tbu), D Thr (tbu), D Asp (Otbu), D Glu (Otbu), D Orn (boc), D Lys (bopc), (d) Z is --NH--CH.sub.3, --NH--CH.sub.2 --CH.sub.3, NH--CH.sub.2 --CH.sub.2 --CH.sub.3, --NH--CH.sub.2 --CH.sub.2 --OH, ##STR1## Y is Leu and X is Gly, (e) Z is --NH--CH.sub.2 -…