Optical isomers

US4981858A · kind A · utility

Assignee

• State of Israel, represented by the Prime Minister's office, Israel Institute for Biological Research CNT ILX COD 07 · IL

Inventors

• Abraham Fisher · Haifa, IL
• Ishal Karton · Nes Ziona, IL
• Eliahu Heidman · Rehovot, IL
• Yona Grunfeld · Rehovot, IL
• Aharon Levy · Beit Hanan, IL

Key dates

• Filing date: Apr 18, 1989
• Grant date: Jan 1, 1991
• Expiry date: Apr 18, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D497/20
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The (+)-cis-, (-)-cis-, (+)-trans- and (-)-trans- forms of 2-methylspiro(1,3-oxathiolan-5,3')quinuclidine are prepared by optical resolution of each of the (.+-.)-cis- and (.+-.)-trans-isomers. These compounds find application in treating diseases of the central nervous system in mammals, especially diseases due to a deficiency in the central cholinergic system. Biological tests indicate that the (-)-cis-form, as well as the (.+-.)-cis-isomer, shows particular promise for treating senile dementia of Alzheimer's type.