Method for inhibition of erythrocyte aggregation using anellated tricyclic compounds

US4981864A · kind A · utility

Assignee

• Boehringer Mannehim GmbH · DE

Inventors

• Wolfgang von der Saal · Rosenheim, DE
• Alfred Mertens · Schriesheim, DE
• Jens-Peter Hoelck · Mannheim, DE
• Erwin Boehm · Ladenburg, DE
• Ulrich Martin · Mannheim, DE

Key dates

• Filing date: Nov 30, 1988
• Grant date: Jan 1, 1991
• Expiry date: Nov 30, 2008

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is concerned with the use of compounds of the general formula: ##STR1## wherein R.sub.1 is a phenyl radical of the general formula: ##STR2## or R.sub.1 is a 5 or 6 membered heterocycle or when X is a valency bond R.sub.1 is also H, OH, mercapto, amino, alkyl, alkenyl, alkynyl, haloalkyl, alkylthio, formylaminoalkyl, pyridylcarbonylamino, cycloalkyl, or cycloalkenyl, alkoxyalkyl, carboxyalkyl, alkoxycarbonylalkyl or hydroxyalkyl of claim 1 or 2 for the preparation of pharmaceutical compositions with an erythrocyte aggregation inhibition action useful, for example, in states of shock or circulatory disturbance.