Derivatives of biliary acids, process for the production thereof and corresponding pharmaceutical compositions
US4981983A · kind A · utility
4Cited by
8References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 2, 1989 |
| Grant date | Jan 1, 1991 |
| Priority date | — |
| Expiry date | Oct 2, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J51/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
New derivatives of chenodeoxycholic, ursodeoxy cholic, cholic and ursocholic acids, bearing a methyl group in the side chain in an alfa position to the carboxylic group, the corresponding nor- and di-nor- derivatives, and the corresponding conjugates with taurine and glycine, are described. The compounds of the invention are prepared by methylation of the esters with methyl iodide in the presence of lithium-dialkylamides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.