Restrictor heating in supercritical fluid chromatography
US4982597A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jul 10, 1989 |
| Grant date | Jan 8, 1991 |
| Priority date | — |
| Expiry date | Jul 10, 2009 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/6013
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
In a system for analyzing a chemical sample by chromatographic separation of said sample into components a method and apparatus are provided for heating the mobile phase to a desired temperature prior to exiting the restrictor, while maintaining the density of the mobile phase at a desired level. Such heating and density maintenance being provided by the combination of a restrictor having a minimal taper length and a temperature zone immediately prior to the outlet end of the restrictor, which temperature zone has a minimum length. A second temperature zone spaced upstream from the first zone, and an intermediate thermally conductive member between the first and second zones can be provided as an alternative embodiment for establishing a thermal gradient. As the mobile phase passes through the second zone, the intermediate conductive member, and the first zone, the mobile phase is subjected to a thermal gradient.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.