Orally administerable ANF
US4983402A · kind A · utility
123Cited by
20References
6Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Feb 24, 1989 |
| Grant date | Jan 8, 1991 |
| Priority date | — |
| Expiry date | Feb 24, 2009 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/2242
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Atrial naturiuretic factor (ANF) is encapsulated within hollow acidic proteinoid microspheres which are stable and protective in the acidic stomach of a mammal but which dissolve at the near neutral pH of the blood. Microspheres having diameters of less than about 10 microns readily penetrate the gastrointestinal mucosa and release the ANF in the bloodstream in physiologically active form. Such gastric administration significantly extends the period of effectiveness of ANF as a diuretic and blood pressure suppressant.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.