Process for preparing 2-aromatic-3-halobenzothiazepines
US4983733A · kind A · utility
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8Claims
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Key dates
| Filing date | Nov 20, 1989 |
| Grant date | Jan 8, 1991 |
| Priority date | — |
| Expiry date | Nov 20, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D281/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
2-Aromatic-3-HALobenzothizepines are prepared by reaction of a 2,3-dihydro-2-aromatic-3-hydroxybenzothiazepine with a thionyl HALide. For example, dl-cis-2-(4-methoxyphenyl)-2,3-dihydro-3-hydroxy-1, 5-benzothiazzepin-4(5H)-one relfuxed with thionyl chloride can prepare E-2-(4-methoxyphenyl)-3-chloro-1,5-benzothiazepin-4(5H)-one in 66 percent yield.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.