Substituted thienylethylamines and process for their production
US4983744A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 24, 1990 |
| Grant date | Jan 8, 1991 |
| Priority date | — |
| Expiry date | Jan 24, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D333/20
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Substituted thienylethylamines of the formula: ##STR1## wherein R is formyl, acetyl or benzoyl or is benzyl, which is ring-substituted by at least one halogen atom, and R.sub.1 is lower alkyl, phenyl or substituted phenyl, are initial products for the production of antithromobolytically effective pharmaceutical agents. A process for the production of the above-mentioned compounds from substituted ethanolamines by their reaction with strong bases, further reaction with the resultant aziridines with 2-thienyllithium, and conversion of the resultant thienylethylamines with compounds of formula RX, wherein R has the above-mentioned meaning and X is a halogen.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.