Process to separate mixtures of enantiomeric arylpropionic acids

US4983765A · kind A · utility

Assignee

• Paz Arzneimittelentwicklungsgesellschaft mbH · DE

Inventors

• Helmut H. Lukas · Carleton Place, CA
• Otto Schuster · Bad Soden, DE
• Gunther Rau · Aachen, DE

Key dates

• Filing date: Jun 27, 1989
• Grant date: Jan 8, 1991
• Expiry date: Jun 27, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C51/487
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process is described in which a mixture of enantiomeric arylpropionic acid is split and one of enantiomeric forms of the acid is recovered. The mixture is transformed into a diastereoisomeric salt by a reaction with a chiralic base and an inert solvent, and the desired acid enantiomer is removed from the reaction product. The transformation to a diastereoisomeric salt takes place in a polar solvent. The salt produced is recrystallized several times and the thus purified salt is split in a dilute mineral acid.