Process of purifying tPA
US4985362A · kind A · utility
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2References
2Claims
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Key dates
| Filing date | Sep 17, 1987 |
| Grant date | Jan 15, 1991 |
| Priority date | — |
| Expiry date | Sep 17, 2007 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/815
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Tissue plasminogen activator (tPA) species having a molecular weight of about 70,000 daltons is isolated in a purified form from a crude tPA preparation containing various tPA species having different molecular weights by bringing the crude tPA preparation into contact with a cation exchanger in advance and separating the desired tPA species selectively from the cation exchanger by means of the salt gradient elution method.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.