Peptides derived from CCK8, their preparation and the pharmaceutical compositions which contain them

US4985406A · kind A · utility

Assignee

• Institut National de la Sante et de la Recherche Medicale (INSERM) · FR

Inventors

• Bruno Charpentier · Biot, FR
• Bernard Roques · Paris, FR

Key dates

• Filing date: Feb 29, 1988
• Grant date: Jan 15, 1991
• Expiry date: Feb 29, 2008

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Peptides of formula: ##STR1## in which X=H or a radical which protects the amine gorup, R=H or SO.sub.3 H, A an D are: PA0 either different, and one of them donotes a radical ##STR2## and the other a radical ##STR3## m and n being between 1 and 5, and A and D form a ring by amidation of their side chains, PA0 or identical or different and denote: ##STR4## with p=1 or 2, and A and D form a ring by oxidative bridging between the sulfphur atoms; B and E=Met, NLe, Leu, Ser, Thr, allo-Thr, or Cys or Hcy, in which the OH or SH groups are free or protected; PA0 F=valency bond or Phe, Tyr(OCH.sub.3) or Cha; PA0 Q=H or alkyl (1 to 6 C), phenyl or phenylalkyl, these radicals being unsubstituted or substituted with fluorine atoms, and the amino acids are D, L or DL; are useful, in particular, as enuropsychotropic drugs.