Ureidoindoles, pharmaceutical compositions and methods for erythrocyte and thrombocyte aggregation inhibition

US4985448A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Harald Zilch · Mannheim, DE
• Alfred Mertens · Schriesheim, DE
• Wolfgang von der Saal · Rosenheim, DE
• Erwin Boehm · Ladenburg, DE
• Klaus Strein · Hemsbach, DE

Key dates

• Filing date: Feb 6, 1989
• Grant date: Jan 15, 1991
• Expiry date: Feb 6, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Lactam compounds of the formula ##STR1## in which: R is hydrogen, alkyl or cycloalkyl; PA0 R.sup.1 is hydrogen, alkyl, alkenyl or cycloalkyl; PA0 R.sup.2 is alkyl, alkenyl, cyano or a carbonyl substituted hydroxyl, alkyl, alkoxy, amino, alkylamino or hydrazino; or PA0 R.sup.1 and R.sup.2 together represent alkylidene cycloalkylidene; or PA0 R.sup.1, R.sup.2 and the adjacent carbon atom form a spirocyclic ring; PA0 n is 0 or 1; PA0 A is a --Co--NH--, --NH--CO--NH-- or --O--CO--NH--; PA0 X is a valency bond, alkylene or alkenylene; and PA0 R.sup.3 is optionally substituted phenyl, pyridyl, methylenedioxyphenyl or a five-membered heterocycle; or when X is a valency bond, R.sup.3 can also be an optionally substituted alkyl or alkino group, or cycloalkyl. The compounds are useful for the inhibition of erythrocyte and thrombocyte aggregation.