Novel cytotoxic protein
US4985541A · kind A · utility
2Cited by
6References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 10, 1987 |
| Grant date | Jan 15, 1991 |
| Priority date | — |
| Expiry date | Apr 10, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/6825
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Purified cytotoxic proteins for use within therapeutic compositions are disclosed. The proteins inhibit protein synthesis in vitro, exhibit abortifacient activity in mice, and contain proline residues with equivalent positions at residue 43 and residue 46 in ricin A-chain. A method for preparing such a cytotoxic protein from the tissue of Trichosanthes kirilowii is also disclosed. The proteins may also be used within a method for inhibiting protein synthesis in selected cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.