Process for preparing optically active tetrahydro-2-furoic acid
US4985575A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Feb 6, 1990 |
| Grant date | Jan 15, 1991 |
| Priority date | — |
| Expiry date | Feb 6, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D307/24
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for preparing an optically active tetrahydro-2-furoic acid is disclosed. The process comprises (i) reacting (.+-.)-tetrahydro-2-furoic acid with an optically active amine resolver of the following formula (I): ##STR1## wherein R.sub.1 is a lower alkyl group and R.sub.2 represents an alkyl group or ar aryl group, provided that R.sub.1 and R.sub.2 are different from each other, thus producing an optically active diastereomer salt, and (ii) decomposing the diastereomer salt. According to the process, a high purity, optically active tetrahydro-2-furoic acid can be prepared at a high yield using an amine resolver. The amine resolver can be recovered at a high yield and high purity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.