Patent · US Expired

Macrocyclic antibiotics

US4987072A · kind A · utility

3Cited by

1References

2Claims

0Family size

Assignee

Gesellschaft fur Biotechnologische Forschung mbH (GBF) · DE

Inventors

Hans Reichenbach · Braunschweig, DE
Gerhard Hofle · Braunschweig, DE
Hermann Augustiniak · Wolfenbüttel, DE
Norbert Bedorf · Königslutter am Elm, DE
Klaus Gerth · Braunschweig, DE
Herbert Irschik · Wittmund, DE
Rolf Jansen · Braunschweig, DE
Brigitte Kunze · Braunschweig, DE
Dietmar Schomburg · Braunschweig, DE
Heinrich Steinmetz · Wennigsen (Deister), DE
Wolfram Trowitzsch-Kienast · Braunschweig, DE
Victor Wray · Braunschweig, DE

Key dates

Filing date	Sep 11, 1986
Grant date	Jan 22, 1991
Priority date	—
Expiry date	Sep 11, 2006

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12P19/623
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The invention relates to cyclic antibiotics of formula ##STR1## wherein the prefix R represents that the substituents on the adjacent carbon atom are in the R configuration; the prefix S represents that the substituents on the adjacent carbon atom are in the S configuration; R.sub.1 is hydrogen or hydroxy and R.sub.2 is hydroxy or .beta.-glucopyranosyloxy, and to the hydrates and salts thereof, especially pharmaceutically acceptable salts. The compounds of formula I are prepared by fermentation using the strain So ce 12 (NCIB 12134) of the species Sorangium celulosum and are effective antiobiotics.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.