Certain 6,7,8,9-tetrahydropyrido[1,2-.alpha.]indoles and their use for the treatment of cerebrovascular disorders

US4987137A · kind A · utility

Assignee

• Beecham-Wuelfing GmbH & Co. KG · DE

Inventors

• Dagmar Hoeltje · Gehrden, DE
• Dietrich Thielke · Wallenstedt, DE

Key dates

• Filing date: Apr 20, 1989
• Grant date: Jan 22, 1991
• Expiry date: Apr 20, 2009

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/28
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound of formula (I) or a pharmaceutically acceptable salt thereof; ##STR1## wherein: R.sub.1 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy or halogen; PA0 R.sub.2 and R.sub.3 are both hydrogen or together represent a bond; PA0 R.sub.4 is hydrogen and R.sub.5 is hydrogen or R.sub.4 and R.sub.5 together represent an oxo group; PA0 R.sub.6 is C.sub.1-7 alkyl substituted by NR.sub.8 R.sub.9 where R.sub.8 and R.sub.9 are independently hydrogen or C.sub.1-4 alkyl or together are C.sub.3-7 polymethylene optionally containing a further heteroatom which is oxygen, sulphur or nitrogen substituted by R.sub.10 where R.sub.10 is hydrogen, C.sub.1-4 alkyl or benzyl, and optionally substituted by one or two C.sub.1-4 alkyl, C.sub.2-5 alkanoyl, C.sub.1-4 alkoxycarbonyl, aminocarbonyl optionally substituted by one or two C.sub.1-6 alkyl groups or by a benzyl group, cyano, phenyl or benzyl and wherein any phenyl or benzyl group is optionally substituted in the phenyl ring by one or two halo, CF.sub.3, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, cyano or nitro groups; and PA0 R.sub.7 is hydrogen or C.sub.1-4 alkyl.