N-hetaryl imidazole derivatives

US4987146A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Ralph Rohde · Berlin, DE
• Helmut Biere · Berlin, DE
• Ralph Schmiechen · Berlin, DE
• John S. Andrews · Cowbridge, GB
• David N. Stephens · Berlin, DE

Key dates

• Filing date: Jul 14, 1989
• Grant date: Jan 22, 1991
• Expiry date: Jul 14, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

N-hetaryl imidazole derivatives of general Formula I ##STR1## are disclosed in which PA0 Het represents an optionally substituted monocyclic or bicyclic heteroaromate, PA0 R.sup.3 represents hydrogen, a straight or branched C.sub.1-6 -alkyl group, or a C.sub.1-6 -alkoxy-alkyl group, and PA0 R.sup.4 represents --COOR.sup.5 --CONR.sup.6 R.sup.7 --CN, ##STR2## with R.sup.5 meaning hydrogen, a straight or branched C.sub.1-6 -alkyl group, R.sup.6 and R.sup.7 are the same of different and represent hydrogen or a straight, branched, or cyclic alkyl group with up to 7 carbon atoms or, together with the nitrogen atom, form a saturated five or six ring optionally containing another heteroatom and R.sup.8 means hydrogen or a straight, branched or cyclic alkyl group with up to 7 carbon atoms.